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Choroidal tuberculosis diagnosed by polymerase chain reaction. A clinicopathologic case report
J D Bowyer1, P D Gormley, R Seth
1Department of Ophthalmology, Queen's Medical Centre, Nottingham, England.
Ophthalmology
|February 10, 1999
Abstract
Purpose:
To show the use of the polymerase chain reaction (PCR) in a granulomatous choroidal lesion to support a diagnosis of tuberculosis.
Design:
Observational case report.
Testing:
Nucleic acid target amplification of a choroidal specimen using PCR for detection of Mycobacterium tuberculosis was tested.
Main Outcome Measures:
Positive nucleic acid target amplification for M. tuberculosis in the ocular sample was measured.
Results:
PCR was positive for M. tuberculosis with appropriate negative controls.
Conclusions:
PCR was thought to be a useful supportive technique in the diagnosis of choroidal tuberculosis.