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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Hypersensitivity reactions to parenteral vitamin K
J Y Chung1, F A Ramos-Caro, B Beers
1Department of Medicine, University of Florida College of Medicine, Gainesville, USA.
Cutis
|February 10, 1999
Summary
Vitamin K1 injections can cause rare skin reactions, typically itchy, hard plaques at the injection site. While most resolve, some may lead to long-lasting scar-like changes.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Cutaneous hypersensitivity reactions to vitamins are uncommon.
- Fat-soluble vitamin K, specifically K1, is implicated in these rare events.
Observation:
- Reactions manifest as pruritic, indurated plaques at the injection site.
- These lesions are typically associated with the administration of vitamin K1.
Findings:
- Most vitamin K1-induced plaques resolve within 4 to 8 weeks.
- A subset of reactions can progress to form persistent scar-like changes.
Implications:
- Understanding these rare reactions is crucial for clinicians managing vitamin K1 therapy.
- Awareness of potential sequelae, including scarring, is important for patient counseling.
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