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In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
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Monoclonal antibodies in solid tumours: approaches to therapy with emphasis on gynaecological cancer

G Fleckenstein1, R Osmers, J Puchta

  • 1Department of Gynecology and Obstetrics, University of Göttingen, Germany.

Medical Oncology (Northwood, London, England)
|February 10, 1999
PubMed

Monoclonal antibodies have progressed from the laboratory to the clinic. Although recognised in diagnosis there are still problems as far as their therapeutic use is concerned. This review looks at the history, principles of active specific immunotherapy, clinical experience with monoclonal antibodies in therapy of solid tumours, in particular the development of new bispecific monoclonal antibodies, and trials in ovarian, breast and colorectal cancer. Immunoconjugates, linked with radionuclides and cytotoxic drugs, indicate future developments. Conditions for successful therapy, especially with adjuvants in patients with small tumour residues, are also described.

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