[Prevention of migraine. Observations on the possibilities offered by some polypeptides]

A biological preparation containing 110a-130a polypeptide fractions with recently discovered antiserotonin and anti-bradykinin activity was employed in the prevention of migraine crises. The overall results were good in trials both versus placebo and using various doses and periods of treatment. Crises were even prevented in a case of cluster headache. Treatment with standard courses giving high doses concentrated in time was apparently successful in antagonising serotonin and bradykinin action on peripheral receptors.