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[Hyperosmolar comatose states]

J M Mantz, J D Tempe, A Jaeger

    Minerva Medica
    |November 14, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Hyperosmolar coma, a condition caused by extracellular hyperosmolarity, presents unique clinical and biological features. This study examines 17 coma cases and their relation to alcohol-induced hyperosmolarity.

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    Area of Science:

    • Clinical Medicine
    • Biochemistry
    • Neurology

    Context:

    • Hyperosmolar coma is a critical condition arising from profound extracellular hyperosmolarity.
    • Understanding its historical context and fundamental pathophysiology is essential for effective management.

    Purpose:

    • To summarize the history and features of hyperosmolar coma.
    • To analyze clinical, biological, and EEG data from 17 treated cases.
    • To investigate the relationship between blood alcohol levels and plasma hyperosmolarity.

    Summary:

    • The study details the clinical peculiarities, such as skin dehydration, and biological markers, including record glycaemia, observed in hyperosmolar coma.
    • Electroencephalogram (EEG) data from 17 patients treated over seven years are presented.

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  • Treatment strategies for hyperosmolar coma remain a subject of debate, with 52 cases of acute drunkenness also analyzed for correlation with plasma hyperosmolarity.

    • Impact:

    • Provides insights into the complex presentation of hyperosmolar coma.
    • Highlights the need for further research into optimal treatment protocols.
    • Establishes a potential link between alcohol consumption and hyperosmolarity, informing public health strategies.