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Related Experiment Videos

A second example of anti-Lu14

W L Marsh, R Oyen, M Rosso

    Transfusion
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    A pregnant woman developed an anti-Lu 14 antibody without prior transfusion, likely from a previous pregnancy. Her second child was unaffected as they did not inherit the Lu14 gene.

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    Area of Science:

    • Immunology
    • Genetics
    • Transfusion Medicine

    Background:

    • The Lutheran blood group system is important in transfusion medicine.
    • The Lu14 antigen is a rare Lutheran blood group antigen.

    Observation:

    • An antibody, anti-Lu 14, was detected in the serum of a gravida 2 pregnant woman.
    • The woman had no history of blood transfusions.

    Findings:

    • The woman's husband expressed the Lu14 antigen.
    • Maternal immunization to the Lu14 antigen likely occurred during her first pregnancy.
    • The second child inherited the ABO and Rh genes from both parents but did not inherit the Lu14 gene from the father, thus remaining unaffected by the maternal anti-Lu14 antibody.

    Implications:

    Related Experiment Videos

    • This case highlights the importance of considering rare blood group antibodies in pregnancy.
    • Understanding maternal immunization and fetal antigen inheritance is crucial for preventing hemolytic disease of the newborn.
    • Further research into the prevalence and clinical significance of anti-Lu 14 is warranted.