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Related Experiment Videos

Incorporation of polymeric nanoparticles into solid dosage forms

C Schmidt1, R Bodmeier

  • 1College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, 12169 Berlin, Germany.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|February 11, 1999
PubMed
Summary

Oral polymeric nanoparticles are crucial for drug delivery. This study found that high minimum film formation temperature (MFT) and good wettability are key for nanoparticle redispersibility from solid dosage forms.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Polymeric nanoparticles are increasingly utilized for oral drug delivery.
  • Their successful application depends on maintaining nanoparticle integrity upon release from solid dosage forms.

Purpose of the Study:

  • To investigate the compatibility of model polymeric nanoparticles with tabletting excipients.
  • To assess the redispersibility of nanoparticles from various solid dosage forms (granules, tablets, pellets, films).
  • To identify critical parameters influencing nanoparticle integrity after release.

Main Methods:

  • Incorporation of Eudragit(R) and Aquacoat(R) nanoparticle dispersions into solid dosage forms.
  • Evaluation of nanoparticle-binder interactions during wet granulation.
  • Assessment of nanoparticle redispersibility and particle size post-release.

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  • Contact angle measurements to determine nanoparticle wettability.

    • Main Results:

    • Phase separation occurred in many nanoparticle/binder systems during wet granulation.
    • High minimum film formation temperature (MFT) and good wettability were critical for nanoparticle redispersibility.
    • Low MFT led to nanoparticle coalescence and poor redispersibility.
    • Contact angle correlated with redispersibility; Eudragit(R) RL showed good redispersibility with low contact angles.

    Conclusions:

    • Maintaining nanoparticle properties requires careful selection of polymers and excipients.
    • Minimum film formation temperature (MFT) and wettability are critical parameters for successful oral nanoparticle formulation.
    • Eudragit(R) RL demonstrates favorable characteristics for redispersibility in oral solid dosage forms.