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Survival analysis for cystic fibrosis in Minas Gerais State, Brazil
F J Reis1, P A Camargos, S de F Rocha
1Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Insights
This study analyzed survival in 111 children with cystic fibrosis (CF) in Brazil. The mean survival age was 12.6 years, highlighting the impact of healthcare and socioeconomic factors on CF patient outcomes.
Area of Science:
- Pediatric Pulmonology
- Clinical Epidemiology
- Public Health
Background:
- Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs.
- Survival rates for CF have significantly improved in developed nations.
- Limited data exists on CF survival in developing countries.
Purpose of the Study:
- To determine the survival rate of pediatric CF patients in Brazil.
- To compare CF survival in Brazil to international benchmarks.
- To identify factors influencing CF patient survival in a developing country context.
Main Methods:
- Survival analysis was performed on 111 pediatric CF patients.
- Data was collected from patients diagnosed and followed at a Brazilian General Hospital.
- Kaplan-Meier (product limit) method was used to construct survival curves and tables.
Main Results:
- The mean survival age for CF patients in this cohort was 12.6 years.
- This life expectancy is comparable to that observed in developed countries around 1970.
- The findings suggest a disparity in survival outcomes compared to contemporary developed nations.
Conclusions:
- Healthcare system organization significantly impacts CF patient survival.
- Unfavorable social and economic conditions in developing countries affect CF outcomes.
- There is a need for improved healthcare infrastructure and socioeconomic support for CF patients in Brazil.
Abstract:
A survival analysis was carried out on cystic fibrosis (CF) patients diagnosed and followed at the General Hospital, Federal University of Minas Gerais, Brazil. The study cohort consisted of 111 children, admitted to the Pediatric Pulmonology Section from 1 June 1970 to 31 December 1994. The survival curve and table, constructed by the Kaplan-Meier (product limit) method, show a mean survival age of 12.6 years. This life expectancy resembles the median survival age observed in developed countries by 1970. This study shows that problems relating to health system organization and unfavourable social and economic conditions in developing countries may directly affect the ultimate survival of CF patients.