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Nutritional effects of a D-methionine-containing solution on AH109A hepatoma-bearing rats
T Sasamura1, A Matsuda, Y Kokuba
1Infusion Research Department, Hoechst Marion Roussel Ltd., Saitama, Japan.
Bioscience, Biotechnology, and Biochemistry
|February 11, 1999
Abstract:
The effects of a D-methionine-containing solution (DMCS) on the nutritional status of AH109A hepatomabearing rats receiving total parenteral nutrition were studied. The DMCS solution inhibited the decrease of transferrin in the plasma of tumor-bearing rats when compared with the effect of an L-methionine-containing solution. The survival time was also significantly prolonged in the DMCS-treated rats. These results indicate that DMCS had a beneficial effect on the malnutrition induced in tumor-bearing rats and would be a useful amino acid solution for the nutritional support of cancer patients.