Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Response phase: a view from the inner hair cell

M A Cheatham1, P Dallos

  • 1Hugh Knowles Center, Northwestern University, Evanston, Illinois 60208-3550, USA. m-cheatham@nwu.edu

The Journal of the Acoustical Society of America
|February 11, 1999
PubMed
Summary

Inner hair cell (IHC) depolarization relates to basilar membrane position, but temporal differences exist between IHC and neural data in the cochlea base. Extracellular voltages and ion channel properties may explain these disparities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The remarkable cochlear amplifier.

Hearing research·2010
Same author

Comment on "Mutual suppression in the 6 kHz region of sensitive chinchilla cochleae" [J. Acoust. Soc. Am. 121, 2805-2818 (2007)].

The Journal of the Acoustical Society of America·2008
Same author

Evaluation of an independent prestin mouse model derived from the 129S1 strain.

Audiology & neuro-otology·2007
Same author

Cochlear function in mice with only one copy of the prestin gene.

The Journal of physiology·2005
Same author

Cochlear function in Prestin knockout mice.

The Journal of physiology·2004
Same author

Intracellular calcium and outer hair cell electromotility.

Brain research·2001

Area of Science:

  • Auditory Neuroscience
  • Cochlear Physiology
  • Hair Cell Biology

Background:

  • Inner hair cell (IHC) responses are crucial for auditory signal transduction.
  • Understanding the relationship between IHC depolarization and basilar membrane mechanics is key to auditory processing.
  • Discrepancies exist between IHC and neural responses, particularly in the cochlear base.

Purpose of the Study:

  • To define the relationship between inner hair cell (IHC) depolarization and basilar membrane position in the guinea pig cochlea.
  • To investigate the factors contributing to temporal disparities between IHC and neural responses in the cochlear base.

Main Methods:

  • Recording IHC responses from the apical three turns of the guinea pig cochlea.
  • Analyzing the relationship between IHC depolarization and basilar membrane velocity.

Related Experiment Videos

  • Comparing IHC data with existing neural response data from different cochlear locations.

    • Main Results:

    • At low frequencies, IHC depolarization aligns with basilar membrane velocity to scala vestibuli in the apex.
    • This differs from the base, where response phase correlates with basilar membrane velocity to scala tympani.
    • Temporal disparities may stem from extracellular voltages, basolateral membrane ion channel kinetics, and frequency-dependent velocity sensitivity.

    Conclusions:

    • Extracellular voltage differences, ion channel properties, and frequency-dependent IHC velocity sensitivity contribute to temporal discrepancies between IHC and neural responses.
    • These factors influence the timing of auditory nerve discharges.
    • Further evaluation is needed to fully understand these cochlear mechanisms.