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Preferential injury of oligodendroblasts by a short hypoxic-ischemic insult
S E Jelinski1, J Y Yager, B H Juurlink
1Department of Anatomy, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Brain Research
|February 12, 1999
Abstract:
One-week-old rat pups were subjected to an acute 10 min severe hypoxic-ischemic insult. Over the next 24 h, during the reperfusion period, O4 immunocytochemistry demonstrated that oligodendroblasts underwent degenerative changes that were coincident with induction of heme oxygenase. We suggest that the increased vulnerability of oligodendroblasts to oxidative stress following an hypoxic-ischemic insult may contribute to the pathogenesis of periventricular leukomalacia.