[Animal experimental studies on the thrombolytic effect of streptokinase]

The thrombolytic action of the streptokinase preparation Awelysin was investigated in animal experiments. After evaluation of the optimum fibrinolytically effective streptokinase dose and the changes in the clotting system induced by intravenous application of streptokinase experimentally produced deposition thrombi and clotting thrombi were lysed intravascularly in dogs, rabbits and rats. The success of the therapy was confirmed angiographically or rheographically.