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Acute effect of ascorbic acid infusion on carbohydrate tolerance
The American Journal of Clinical Nutrition
|December 1, 1976
Summary
High-dose intravenous ascorbic acid (vitamin C) did not affect glucose tolerance or fasting glucose in normal or obese individuals. However, it lowered insulin levels during glucose testing in normal-weight subjects.
Area of Science:
- Biochemistry
- Endocrinology
- Metabolic Research
Background:
- Ascorbic acid (vitamin C) is a vital nutrient with antioxidant properties.
- Its role in glucose metabolism and insulin sensitivity is not fully understood.
- Previous research suggests potential links between vitamin C and metabolic health.
Purpose of the Study:
- To investigate the effects of high-dose intravenous ascorbic acid on glucose tolerance and related hormonal responses.
- To assess these effects in both normal weight and obese non-diabetic individuals.
Main Methods:
- Intravenous administration of large doses (1-2g/3hr) of ascorbic acid.
- Monitoring of plasma glucose, serum insulin, growth hormone, and glucagon levels.
- Inclusion of normal weight and obese, non-diabetic subjects.
Main Results:
- Intravenous ascorbic acid did not alter glucose tolerance or fasting plasma glucose levels.
- A significant increase in plasma ascorbic acid concentrations was observed.
- Fasting serum insulin levels were unaffected in normal subjects, but decreased during glucose tolerance tests.
- Obese subjects showed no changes in glucose, insulin, growth hormone, or glucagon levels.
Conclusions:
- High-dose intravenous ascorbic acid does not impair glucose tolerance or fasting glucose levels in non-diabetic individuals.
- Vitamin C may influence insulin dynamics during glucose challenges, particularly in normal-weight individuals.
- Further research is needed to clarify the specific mechanisms and clinical implications.