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Related Experiment Videos

Stabilization of dithranol in topical formulations

K Thoma1, C Holzmann

  • 1Department of Pharmaceutical Technology, Ludwig-Maximilians-University Munich, Germany. Prof.Thoma@lrz.uni-muenchen.de

Acta Pharmaceutica Hungarica
|February 13, 1999
PubMed
Summary

Investigating dithranol stability in topical formulations revealed that drug concentration and solubility significantly impact degradation. Certain stabilizers, like succinic and tartaric acids, effectively protect this antipsoriatic drug.

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Area of Science:

  • Pharmaceutical Sciences
  • Dermatology
  • Drug Formulation

Background:

  • Dithranol is a key antipsoriatic drug used in topical formulations.
  • Understanding factors affecting dithranol stability is crucial for effective treatment.
  • Previous research has not fully elucidated the complex interactions influencing its degradation in various bases.

Purpose of the Study:

  • To investigate the influence of various factors on the stability of dithranol in topical formulations.
  • To evaluate the efficacy of different stabilizers in preventing dithranol degradation.
  • To determine the optimal conditions for maintaining dithranol integrity in pharmaceutical preparations.

Main Methods:

  • Dithranol stability was assessed in lipophilic, hydrophilic, and cream bases.
  • Factors studied included drug concentration, temperature, pH, humidity, solubility, and stabilizers.
  • Drug degradation was quantified using a selective High-Performance Liquid Chromatography (HPLC) system.

Main Results:

  • Dithranol degradation showed a strong dependency on drug concentration.
  • Solubility in the ointment base was identified as a critical factor, with higher solubility accelerating degradation.
  • Temperature had a less significant impact compared to pH and buffer system choice.
  • Succinic acid and tartaric acid were found to be highly effective stabilizers.

Conclusions:

  • Dithranol stability in topical formulations is significantly influenced by drug concentration and solubility.
  • Optimizing formulation pH, buffer system, and incorporating specific stabilizers are essential for enhancing dithranol stability.
  • Succinic acid and tartaric acid show promise as effective agents for protecting dithranol from degradation.

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