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Suppressed apoptotic susceptibility in human endometrial epithelial cells pretreated with hepatocyte growth factor
T Tanaka1, K Mizuno, N Umesaki
1Department of Obstyetrics & Gynecology, Osaka City University Medical School, Japan.
Clinical and Experimental Obstetrics & Gynecology
|February 13, 1999
Abstract:
Hepatocyte growth factor (HGF) and its receptor are strongly expressed perimenstrually in human endometrial epithelium, but their functions remain unknown. In this study the effects of HGF on Fas-mediated apoptosis in the human endometrial epithelial cell line HHUA were investigated. It was found that HGF inhibited Fas-mediated growth suppression and DNA fragmentation in the cells without any increase in Fas antigen expression on the cells. This results suggests that HGF inhibits Fas-mediated apoptotic signals in the endometrium, and possibly plays a role in reshaping the endometrium during menstruation.