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Quantification of intraocular retained perfluorodecalin after macroscopic complete removal
M Winter1, C Winter, B Wiechens
1Department of Ophthalmology, University of Kiel, Germany. mwinter@ophthalmol.uni-kiel.de
Summary
Even after complete removal, perfluorodecalin (PFC) liquid can remain on the retina. Multiple rinses with saline solution are recommended after fluid-gas exchange to minimize retained PFC.
Area of Science:
- Ophthalmology
- Retinal Surgery
- Surgical Fluids
Background:
- Perfluorodecalin (PFC) is used in retinal detachment surgery.
- Complete removal of intraocular PFC is crucial for patient outcomes.
- Quantifying residual PFC after removal is essential.
Purpose of the Study:
- To determine the amount of intraocular perfluorodecalin retained after macroscopic complete removal.
- To evaluate the impact of fluid-air exchange and rinsing on residual PFC levels.
Main Methods:
- Pig eyes underwent vitrectomy and fluid-air exchange.
- Perfluorodecalin was instilled, macroscopically removed, and retinas were rinsed.
- Residual PFC was quantified using gas chromatography after dissolution in perfluoropolyether.
Main Results:
- Perfluorodecalin was retained in all experiments.
- The lowest retention (0.058%) occurred without fluid-air exchange.
- Fluid-air exchange with rinsing resulted in 0.21% retention, and without rinsing, 0.60% retention.
Conclusions:
- A thin layer of perfluorodecalin remains on the retina even after apparent complete removal.
- Multiple saline rinses are recommended following intraoperative fluid-gas exchange to minimize retained perfluorocarbon liquid.