Related Experiment Video
Updated: Aug 11, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
[Hormones and auto-paracrine tumor growth regulators in osteogenic sarcoma]
Abstract:
The paper analyzes the data of long-term studies made in the N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences. The study dealt with androgen exchange, the baseline levels of serum sexual steroid hormones and their receptors in the tumor, the blood concentrations of the sexual steroids conjugated globulin and pituitary hormone, the metabolism of arachidonic acid, the expression of epidermal growth factor and its ligands, the amount of calmodulin, cAMP in the osteogenic sarcoma in 300 patients aged 14-56 years. Analyzing the findings suggests that there are some directions in studies, development, and practical introduction of new pathogenetic therapies of osteosarcoma, which are associated with the regulation of androgen exchange, the correction of the cyclooxygenase pathway of arachidonic acid, expression of receptors of epidermal growth factor and its ligands in the tumor.
Related Concept Videos
Autocrine Signaling
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Mitogens and the Cell Cycle
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Regulation of Angiogenesis and Blood Supply
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

