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Mapping susceptibility genes for asthma and allergy
1Center for the Genetics of Asthma and Complex Diseases, University of Maryland, Baltimore 21201, USA.
Summary
Genetic linkage analysis reveals multiple genomic regions linked to allergy and asthma susceptibility. Environmental interactions with these genes influence disease development and treatment response.
Area of Science:
- Genetics
- Immunology
- Environmental Health
Background:
- Allergy and asthma are complex diseases with a significant genetic component.
- Identifying specific susceptibility genes is crucial for understanding disease mechanisms.
Purpose of the Study:
- To review and compare results from genome screen studies and candidate gene approaches.
- To identify genomic regions containing susceptibility genes for allergy and asthma.
Main Methods:
- Family-based linkage analysis was used to map susceptibility genes.
- Results from two genome screen studies were compared with candidate gene approaches.
Main Results:
- Multiple genomic regions show evidence for linkage to atopy, asthma, and related phenotypes (e.g., total serum IgE).
- Chromosomes 5, 6, 11, 12, 13, and 14 harbor potential susceptibility genes.
- These regions contain candidate genes involved in allergy and asthma development and progression.
Conclusions:
- Susceptibility to allergy and asthma is polygenic, involving multiple genes interacting with environmental factors.
- Some identified genes may influence disease expression or therapeutic response.