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HIV, UV and immunosuppression

R Akaraphanth1, H W Lim

  • 1Institute of Dermatology, Bangkok, Thailand.

Photodermatology, Photoimmunology & Photomedicine
|February 17, 1999
PubMed
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Ultraviolet (UV) radiation, used in phototherapy and photochemotherapy, is safe for treating skin conditions in individuals with human immunodeficiency virus (HIV). Studies show no adverse effects, addressing concerns about UV

Area of Science:

  • Dermatology and Immunology
  • Photomedicine

Background:

  • Cutaneous diseases are frequent in human immunodeficiency virus (HIV) patients.
  • Phototherapy (UVB) and photochemotherapy (PUVA) effectively treat various skin conditions like psoriasis and eczema.
  • Concerns exist regarding UV radiation's immunosuppressive effects on HIV-infected individuals.

Purpose of the Study:

  • To review the safety of UV-based therapies in HIV-infected individuals.
  • To evaluate potential adverse effects of phototherapy and photochemotherapy in the context of HIV infection.

Main Methods:

  • In vitro studies on HIV-infected cell lines.
  • Animal model studies.
  • Human clinical studies.

Main Results:

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  • UV radiation, as employed in phototherapy and photochemotherapy, demonstrated no adverse effects in HIV-infected individuals.
  • Available data from cell lines, animal models, and human studies support the safety of these UV treatments.

Conclusions:

  • Phototherapy and photochemotherapy are safe treatment options for cutaneous diseases in individuals with HIV.
  • Current evidence suggests UV radiation does not negatively impact HIV-infected patients undergoing these dermatological treatments.