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[Effect of kanamycin on kidney function in children with suppurative, inflammatory diseases]
Insights
Kanamycin did not harm kidney function in children, even at higher doses. Combining kanamycin with pentoxyl improved kidney function and reduced protein and white blood cells in urine.
Area of Science:
- Pediatric Nephrology
- Infectious Diseases
- Pharmacology
Context:
- Kanamycin is an antibiotic used to treat serious bacterial infections.
- Nephrotoxicity is a known potential side effect of kanamycin therapy.
- Pyrimidines, like pentoxyl, are being investigated for their potential to mitigate antibiotic side effects.
Purpose:
- To evaluate the nephrotoxic effects of kanamycin in pediatric patients.
- To assess the efficacy of pentoxyl in reducing kanamycin-induced kidney damage.
- To determine safe and effective therapeutic doses of kanamycin in children.
Summary:
- A study involving 240 children (2 months to 14 years) with osteomyelitis or staphylococcal lung infections investigated kanamycin's renal effects.
- Kanamycin, administered at 15,000-25,000 Units/kg for 6-7 days, showed no nephrotoxic impact.
- Concurrent administration with pentoxyl, a pyrimidine derivative, significantly enhanced kidney function, indicated by improved residual nitrogen levels and glomerular filtration, and reduced albuminuria and leucocyturia.
Impact:
- The findings support the use of higher therapeutic doses of kanamycin (up to 25,000 Units/kg) in pediatric patients.
- This research highlights the potential of pentoxyl to mitigate kanamycin's adverse renal effects.
- Constant monitoring of kidney function is recommended when using these higher kanamycin dosages.
Abstract:
The effect of kanamycin on the kidney function and the possibility of decreasing its side effect of pyrimidines were studied in240 children at the age of 2 month to 14 years (161 children with acute and chronic osteomyelitis and 79 children with staphylococcal destruction of the lungs). Kanamycin used in doses of 15000 and 25000 Units/kg of the body weight for 6 to 7 days in treatment of the children with staphylococcal destruction of the lungs, acute and chronic osteomyelitis had no nephrotoxic effect. Combination of kanamycin with pentoxyl, pryimidine derivative significantly improved the kidney function, which was evident from the content of the residual nitrogen in the blood serum and increased glomerural filtration. Combined use of kanamycin with pentoxyl promoted a decrease in albuminuria and leucocyturia. The data of the study provided recommendation of increased therapeutic doses of kanamycin, up to 15000--25000 Units/kg of the body weight in accordance with the recommendations under conditions of constant control of the kidney function.