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Lichen planus pemphigoides. Immunofluorescence findings

S Sobel, R Miller, H Shatin

Archives of Dermatology

|September 1, 1976

Summary

Lichen planus pemphigoides, a rare skin condition, presents with blisters and lichenoid papules. Immunofluorescence studies suggest a shared autoimmune mechanism with lichen planus.

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Area of Science:

Dermatology
Immunology
Pathology

Background:

Lichen planus pemphigoides is a rare autoimmune blistering disease.
It shares clinical and histological features with both lichen planus and bullous pemphigoid.

Observation:

A 56-year-old woman presented with a vesicular and bullous eruption followed by lichenoid papules.
Clinical and histological findings were consistent with lichen planus pemphigoides.

Findings:

Direct and indirect immunofluorescence studies revealed IgG antibodies targeting the epidermal basement membrane zone.
These antibodies were both in vivo-bound and circulating.

Implications:

The findings suggest a common pathogenic immunologic mechanism underlies lichen planus and lichen planus pemphigoides.
Lichen planus pemphigoides may represent a clinical variant of lichen planus.

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