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Acquired generalized anhidrosis

T Tsuji, T Yamamoto

    Archives of Dermatology
    |September 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Sunstroke may cause generalized anhidrosis (inability to sweat) due to heat-induced damage to eccrine sweat glands. This study reveals cellular changes in sweat glands, suggesting autolysis and lysosome involvement in heat-related anhidrosis.

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    Area of Science:

    • Dermatology
    • Pathology
    • Environmental Medicine

    Background:

    • Generalized anhidrosis is a rare condition affecting the body's ability to sweat.
    • Sunstroke (heatstroke) can lead to severe systemic effects, including potential skin dysfunction.

    Observation:

    • A patient presented with generalized anhidrosis following an episode of sunstroke.
    • Microscopic examination revealed atrophic eccrine sweat glands with vacuolated secretory cells.
    • Ultrastructural analysis identified these vacuoles as lysosomes containing cellular debris, indicative of autolysis.

    Findings:

    • The eccrine sweat glands exhibited significant pathological changes, including lobulation and elongation.
    • Vacuoles within the sweat gland cells demonstrated high acid phosphatase activity, a marker for lysosomes.

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  • Evidence of cellular autolysis and lysosomal activity was observed within the secretory cells.

    • Implications:

    • The findings suggest a direct link between severe heat exposure (sunstroke) and the pathological alteration of eccrine sweat glands.
    • Autolysis and lysosomal dysfunction in sweat gland cells are proposed mechanisms leading to heat-induced anhidrosis.
    • Understanding these cellular changes could inform future treatments for heat-related disorders and anhidrosis.