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ACS Medicinal Chemistry Letters|July 19, 2023
Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric ModulatorsJames J Perkins, Paul McQuade, Christopher J Bungard, et al.Bioorganic & Medicinal Chemistry Letters|February 21, 2017
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonistsJason W Skudlarek, Christina N DiMarco, Kerim Babaoglu, et al.Chemmedchem|December 31, 2013
Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaAnthony J Roecker, Swati P Mercer, John D Schreier, et al.ACS Medicinal Chemistry Letters|January 17, 2024
Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose ProjectionsH Marie Loughran, Kathy M Schirripa, Anthony J Roecker, et al.Bioorganic & Medicinal Chemistry Letters|April 9, 2017
Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in miceAnthony J Roecker, Melissa Egbertson, Kristen L G Jones, et al.Bioorganic & Medicinal Chemistry Letters|September 25, 2014
Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaAnthony J Roecker, Thomas S Reger, M Christa Mattern, et al.ACS Medicinal Chemistry Letters|February 16, 2023
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's DiseaseAnthony J Roecker, Kathy M Schirripa, H Marie Loughran, et al.Journal of Medicinal Chemistry|June 23, 2010
Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomniaChristopher D Cox, Michael J Breslin, David B Whitman, et al.Journal of Medicinal Chemistry|February 16, 2024
Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine MimicValerie W Shurtleff, Mark E Layton, Craig A Parish, et al.Pageof 3