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ACS Chemical Neuroscience|January 18, 2024
Identification of a Novel Subtype-Selective α1B-Adrenoceptor AntagonistAlaa Abdul-Ridha, Lazarus A de Zhang, Ashenafi Haileyesus Betrie, et al.SLAS Discovery : Advancing Life Sciences R & D|September 15, 2023
Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensorsEdward A FitzGerald, Darius Vagrys, Giulia Opassi, et al.RSC Medicinal Chemistry|December 22, 2022
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinatesS Paul Jones, James D Firth, Mary C Wheldon, et al.Journal of Medicinal Chemistry|October 23, 2024
Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo ActivityAttila Vasas, Lisa Ivanschitz, Balázs Molnár, et al.Bioorganic & Medicinal Chemistry Letters|June 16, 2007
Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scopingChristine M Richardson, Claire L Nunns, Douglas S Williamson, et al.ACS Omega|January 26, 2026
Targeting PTPN22 at Nonorthosteric Binding SitesA Fragment ApproachPaola Di Lello, Marta M Wells, Ben Davis, et al.RSC Medicinal Chemistry|November 25, 2022
PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discoveryHuiyong Ma, James B Murray, Huadong Luo, et al.Chemical Science|October 3, 2025
Design, modular synthesis and screening of 58 shape-diverse 3-D fragmentsThomas D Downes, S Paul Jones, James D Firth, et al.Chemistry (Weinheim an Der Bergstrasse, Germany)|April 22, 2020
Design and Synthesis of 56 Shape-Diverse 3D FragmentsThomas D Downes, S Paul Jones, Hanna F Klein, et al.RSC Medicinal Chemistry|December 18, 2023
A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinaseNaoki Kuki, David L Walmsley, Kazuo Kanai, et al.Pageof 8