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Cancer Letters
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January 27, 2019
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models
Tingting Lu, Cheng Chen, Aoli Wang, et al.
Investigational New Drugs
|
December 25, 2019
Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models
Li Wang, Chen Hu, Aoli Wang, et al.
Haematologica
|
April 18, 2020
Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia
Aoli Wang, Chen Hu, Cheng Chen, et al.
Journal of Medicinal Chemistry
|
December 20, 2018
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia
Xiaofei Liang, Beilei Wang, Cheng Chen, et al.
Oncotarget
|
April 15, 2017
Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode
Chen Hu, Aoli Wang, Hong Wu, et al.
Oncotarget
|
January 18, 2018
Discovery of a highly selective KIT kinase primary V559D mutant inhibitor for gastrointestinal stromal tumors (GISTs)
Kailin Yu, Xuesong Liu, Zongru Jiang, et al.
Cancer Biology & Therapy
|
March 22, 2019
Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML)
Jiaxin Wu, Aoli Wang, Xixiang Li, et al.
Journal of Medicinal Chemistry
|
March 11, 2017
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode
Aoli Wang, Xixiang Li, Hong Wu, et al.
European Journal of Medicinal Chemistry
|
September 26, 2018
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor
Beilei Wang, Jiaxin Wu, Yun Wu, et al.
Scientific Reports
|
March 30, 2017
Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model
Hong Wu, Qiong Huang, Ziping Qi, et al.
Page
of 18
Search research articles
Search
Showing results (151-160 of 173) with videos related to
Sort By:
Page
of 18
Cancer Letters
|
January 27, 2019
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models
Tingting Lu, Cheng Chen, Aoli Wang, et al.
Investigational New Drugs
|
December 25, 2019
Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models
Li Wang, Chen Hu, Aoli Wang, et al.
Haematologica
|
April 18, 2020
Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia
Aoli Wang, Chen Hu, Cheng Chen, et al.
Journal of Medicinal Chemistry
|
December 20, 2018
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia
Xiaofei Liang, Beilei Wang, Cheng Chen, et al.
Oncotarget
|
April 15, 2017
Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode
Chen Hu, Aoli Wang, Hong Wu, et al.
Oncotarget
|
January 18, 2018
Discovery of a highly selective KIT kinase primary V559D mutant inhibitor for gastrointestinal stromal tumors (GISTs)
Kailin Yu, Xuesong Liu, Zongru Jiang, et al.
Cancer Biology & Therapy
|
March 22, 2019
Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML)
Jiaxin Wu, Aoli Wang, Xixiang Li, et al.
Journal of Medicinal Chemistry
|
March 11, 2017
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode
Aoli Wang, Xixiang Li, Hong Wu, et al.
European Journal of Medicinal Chemistry
|
September 26, 2018
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor
Beilei Wang, Jiaxin Wu, Yun Wu, et al.
Scientific Reports
|
March 30, 2017
Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model
Hong Wu, Qiong Huang, Ziping Qi, et al.
Page
of 18