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Cell Reports|April 25, 2019
An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent NeurodegenerationBrittany N Flores, Xingli Li, Ahmed M Malik, et al.
Acta Neuropathologica Communications|August 6, 2020
The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTDFang He, Brittany N Flores, Amy Krans, et al.
Plos One|October 25, 2016
Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal ToxicityBrittany N Flores, Mark E Dulchavsky, Amy Krans, et al.
The Journal of Biological Chemistry|October 26, 2019
High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translationKatelyn M Green, Udit J Sheth, Brittany N Flores, et al.
Nature Communications|December 10, 2017
RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress responseKatelyn M Green, M Rebecca Glineburg, Michael G Kearse, et al.
Nucleic Acids Research|July 29, 2022
CGG repeats trigger translational frameshifts that generate aggregation-prone chimeric proteinsShannon E Wright, Caitlin M Rodriguez, Jeremy Monroe, et al.
EMBO Reports|July 27, 2019
DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translationAlexander E Linsalata, Fang He, Ahmed M Malik, et al.
Nature Neuroscience|February 19, 2020
A native function for RAN translation and CGG repeats in regulating fragile X protein synthesisCaitlin M Rodriguez, Shannon E Wright, Michael G Kearse, et al.
Journal of Medicinal Chemistry|March 21, 2024
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative DiseasesRobert A Craig, Javier De Vicente, Anthony A Estrada, et al.
Cell Reports|August 11, 2015
Exome Sequence Analysis Suggests that Genetic Burden Contributes to Phenotypic Variability and Complex NeuropathyClaudia Gonzaga-Jauregui, Tamar Harel, Tomasz Gambin, et al.
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