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Journal of the American Chemical Society|May 2, 2002
Chromophore formation in resorcinarene solutions and the visual detection of mono- and oligosaccharidesMing He, Rolanda J Johnson, Jorge O Escobedo, et al.
Bioorganic & Medicinal Chemistry Letters|September 2, 2014
Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354Wandong Wen, Summer E Young, Matthew T Duvernay, et al.
Bioorganic & Medicinal Chemistry Letters|September 21, 2011
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071Evan P Lebois, Gregory J Digby, Douglas J Sheffler, et al.
ACS Pharmacology & Translational Science|June 21, 2021
Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 FibroblastsDana L Cruz, Nina Pipalia, Shu Mao, et al.
Bioorganic & Medicinal Chemistry Letters|December 27, 2011
Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012Bruce J Melancon, Alexander P Lamers, Thomas M Bridges, et al.
ACS Chemical Neuroscience|August 8, 2018
Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M1 Positive Allosteric ModulatorsJulie L Engers, Aaron M Bender, Jacob J Kalbfleisch, et al.
Bioorganic & Medicinal Chemistry Letters|April 18, 2012
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptorBruce J Melancon, Rocco D Gogliotti, James C Tarr, et al.
Bioorganic & Medicinal Chemistry Letters|November 27, 2012
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophreniaUyen Le, Bruce J Melancon, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|November 2, 2017
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amidesJames C Tarr, Michael R Wood, Meredith J Noetzel, et al.
Bioorganic & Medicinal Chemistry Letters|December 13, 2016
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogsMichael R Wood, Meredith J Noetzel, Michael S Poslusney, et al.
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