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Life Science Alliance|March 13, 2025
The late-onset Alzheimer's disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysisGeorg Jocher, Gozde Ozcelik, Stephan A Müller, et al.Cell Reports|April 23, 2026
Structural basis for ADAM17 activation by the iRhom1 pseudoproteaseJoseph N Ungvary, Joseph J Maciag, Hala F Alnajjar, et al.Nature Immunology|October 31, 2006
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23Gisela Weskamp, Jill W Ford, Jamie Sturgill, et al.EMBO Reports|May 9, 2022
ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusionGeorg Jocher, Vincent Grass, Sarah K Tschirner, et al.Science (New York, N.Y.)|January 17, 2012
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPSDavid R McIlwain, Philipp A Lang, Thorsten Maretzky, et al.The Journal of Clinical Investigation|January 26, 2013
iRHOM2 is a critical pathogenic mediator of inflammatory arthritisPriya Darshinee A Issuree, Thorsten Maretzky, David R McIlwain, et al.Science Translational Medicine|August 17, 2018
A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivityWilliam D Shipman, Susan Chyou, Anusha Ramanathan, et al.Science Signaling|November 5, 2015
Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17Sathish K Maney, David R McIlwain, Robin Polz, et al.Elife|June 11, 2024
The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupusThomas Morgan Li, Victoria Zyulina, Ethan S Seltzer, et al.American Journal of Human Genetics|May 5, 2009
Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in miceDavid A Parry, Carmel Toomes, Lina Bida, et al.Pageof 10