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Cancer Discovery|July 27, 2018
SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer ModelsCarmine Fedele, Hao Ran, Brian Diskin, et al.
Oncotarget|May 28, 2015
Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contactsMarco Trerotola, Kirat K Ganguly, Ladan Fazli, et al.
Cancer Research|July 25, 2016
αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen ReceptorHuimin Lu, Tao Wang, Jing Li, et al.
Matrix Biology : Journal of the International Society for Matrix Biology|August 12, 2018
Prostate cancer sheds the αvβ3 integrin in vivo through exosomesShiv Ram Krishn, Amrita Singh, Nicholas Bowler, et al.
Cancer Discovery|August 6, 2021
Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLCKwan Ho Tang, Shuai Li, Alireza Khodadadi-Jamayran, et al.
Cancer Research|November 7, 2023
CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non-Small Cell Lung CancerAnirudh Prahallad, Andreas Weiss, Hans Voshol, et al.
The Journal of Experimental Medicine|October 12, 2020
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodelingCarmine Fedele, Shuai Li, Kai Wen Teng, et al.
Matrix Biology : Journal of the International Society for Matrix Biology|March 14, 2018
Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancerHuimin Lu, Nicholas Bowler, Larry A Harshyne, et al.
Nature Immunology|March 11, 2020
PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancerBrian Diskin, Salma Adam, Marcelo F Cassini, et al.
Cancer Discovery|April 11, 2022
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12CAndreas Weiss, Edwige Lorthiois, Louise Barys, et al.
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