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Bioorganic & Medicinal Chemistry Letters|September 26, 2015
Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modificationsJongwon Lim, Michael D Altman, James Baker, et al.Bioorganic & Medicinal Chemistry Letters|December 22, 2009
Piperazinyl pyrimidine derivatives as potent gamma-secretase modulatorsAlexey Rivkin, Sean P Ahearn, Stephanie M Chichetti, et al.Bioorganic & Medicinal Chemistry Letters|November 24, 2019
Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitorsHua Zhou, Meredeth A McGowan, Kathryn Lipford, et al.Journal of Medicinal Chemistry|February 6, 2013
Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-MetAlan B Northrup, Matthew H Katcher, Michael D Altman, et al.Journal of Medicinal Chemistry|April 16, 2019
Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved TolerabilityJoey L Methot, Hua Zhou, Sam D Kattar, et al.Journal of Medicinal Chemistry|April 2, 2021
Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ ImmunomodulatorsJoey L Methot, Hua Zhou, Meredeth A McGowan, et al.Bioorganic & Medicinal Chemistry Letters|July 6, 2015
Potent benzoazepinone γ-secretase modulators with improved bioavailabilityJoey L Methot, Christian Fischer, Chaomin Li, et al.Bioorganic & Medicinal Chemistry Letters|April 10, 2012
Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitorsJoshua Close, Richard Heidebrecht, John Hendrix, et al.Journal of Medicinal Chemistry|October 29, 2021
Discovery of <b>MK-4688</b>: an Efficient Inhibitor of the HDM2-p53 Protein-Protein InteractionMichael H Reutershan, Michelle R Machacek, Michael D Altman, et al.Bioorganic & Medicinal Chemistry Letters|May 15, 2017
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammationGraham F Smith, Michael D Altman, Brian Andresen, et al.Pageof 4