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Journal of Immunology (Baltimore, Md. : 1950)|April 23, 2003
Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis modelDavid Claveau, Mirna Sirinyan, Jocelyne Guay, et al.
Life Sciences|November 30, 2005
Preferential inhibition of human phosphodiesterase 4 by ibudilastZheng Huang, Susana Liu, Lei Zhang, et al.
Journal of Lipid Research|June 7, 2011
Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitorsFrance Landry, Chi-Chung Chan, Zheng Huang, et al.
The Journal of Clinical Investigation|October 9, 2002
Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesisAnnette Robichaud, Panagiota B Stamatiou, S-L Catherine Jin, et al.
Bioorganic & Medicinal Chemistry Letters|February 9, 2010
SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitorsYeeman K Ramtohul, Cameron Black, Chi-Chung Chan, et al.
European Journal of Pharmacology|February 24, 2007
Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical speciesSteven E Rowland, Patsy Clark, Robert Gordon, et al.
Diabetes|July 8, 2009
The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activationYaël Mamane, Chi Chung Chan, Genevieve Lavallee, et al.
Bioorganic & Medicinal Chemistry Letters|February 16, 2008
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating proteinDwight Macdonald, Christine Brideau, Chi Chung Chan, et al.
Bioorganic & Medicinal Chemistry Letters|March 18, 2003
Pyridazinones as selective cyclooxygenase-2 inhibitorsChun Sing Li, Christine Brideau, Chi Chung Chan, et al.
Bioorganic & Medicinal Chemistry Letters|November 16, 2010
Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitorsElise Isabel, David A Powell, W Cameron Black, et al.
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