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Christopher J Winrow

Showing results (51-60 of 59) with videos related to

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Scientific Reports|June 4, 2016
Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to ManAnthony L Gotter, Mark S Forman, Charles M Harrell, et al.
Bioorganic & Medicinal Chemistry Letters|January 12, 2015
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexantIzzat T Raheem, Michael J Breslin, Joseph Bruno, et al.
Science Translational Medicine|April 5, 2013
Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognitionJason M Uslaner, Spencer J Tye, Donnie M Eddins, et al.
Chemmedchem|May 7, 2009
Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in ratsDavid B Whitman, Christopher D Cox, Michael J Breslin, et al.
Bioorganic & Medicinal Chemistry Letters|February 21, 2017
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonistsJason W Skudlarek, Christina N DiMarco, Kerim Babaoglu, et al.
Chemmedchem|December 31, 2013
Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaAnthony J Roecker, Swati P Mercer, John D Schreier, et al.
Chemmedchem|February 7, 2012
Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting propertiesPaul J Coleman, John D Schreier, Christopher D Cox, et al.
Bioorganic & Medicinal Chemistry Letters|September 25, 2014
Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaAnthony J Roecker, Thomas S Reger, M Christa Mattern, et al.
Journal of Medicinal Chemistry|June 23, 2010
Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomniaChristopher D Cox, Michael J Breslin, David B Whitman, et al.
Pageof 6

Showing results (51-60 of 59) with videos related to

Sort By:
Pageof 6
You have reached the last page of results.This site can display upto 59 results.
Scientific Reports|June 4, 2016
Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to ManAnthony L Gotter, Mark S Forman, Charles M Harrell, et al.
Bioorganic & Medicinal Chemistry Letters|January 12, 2015
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexantIzzat T Raheem, Michael J Breslin, Joseph Bruno, et al.
Science Translational Medicine|April 5, 2013
Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognitionJason M Uslaner, Spencer J Tye, Donnie M Eddins, et al.
Chemmedchem|May 7, 2009
Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in ratsDavid B Whitman, Christopher D Cox, Michael J Breslin, et al.
Bioorganic & Medicinal Chemistry Letters|February 21, 2017
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonistsJason W Skudlarek, Christina N DiMarco, Kerim Babaoglu, et al.
Chemmedchem|December 31, 2013
Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaAnthony J Roecker, Swati P Mercer, John D Schreier, et al.
Chemmedchem|February 7, 2012
Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting propertiesPaul J Coleman, John D Schreier, Christopher D Cox, et al.
Bioorganic & Medicinal Chemistry Letters|September 25, 2014
Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaAnthony J Roecker, Thomas S Reger, M Christa Mattern, et al.
Journal of Medicinal Chemistry|June 23, 2010
Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomniaChristopher D Cox, Michael J Breslin, David B Whitman, et al.
Pageof 6