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Journal of Medicinal Chemistry|October 21, 2022
Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists <b>BAY-4931</b> and <b>BAY-0069</b>Douglas L Orsi, Elisabeth Pook, Nico Bräuer, et al.Journal of Virology|April 13, 2012
Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA proteinChristopher T Lemke, Steve Titolo, Uta von Schwedler, et al.Bioorganic & Medicinal Chemistry|December 21, 2022
Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonistsDouglas L Orsi, Steven J Ferrara, Stephan Siegel, et al.Nature Cancer|August 23, 2024
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor modelsUlrike Rauh, Guo Wei, Michael Serrano-Wu, et al.Nature Genetics|December 3, 2021
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancersTakahiro Ito, Michael J Young, Ruitong Li, et al.Bioorganic & Medicinal Chemistry Letters|November 20, 2010
Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assemblyLee D Fader, Richard Bethell, Pierre Bonneau, et al.Nature|July 13, 2022
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complexJason J Kwon, Behnoush Hajian, Yuemin Bian, et al.Nature Communications|July 17, 2021
Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNaseColin W Garvie, Xiaoyun Wu, Malvina Papanastasiou, et al.Biorxiv : the Preprint Server for Biology|November 1, 2024
Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activityJason J Kwon, Julien Dilly, Shengwu Liu, et al.The Journal of Biological Chemistry|July 30, 2020
Multimodal small-molecule screening for human prion protein bindersAndrew G Reidenbach, Michael F Mesleh, Dominick Casalena, et al.Pageof 4