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Bioorganic & Medicinal Chemistry Letters|February 6, 2019
Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activatorsSwagat Sharma, Krystian A Kozek, Kristopher K Abney, et al.
Drug News & Perspectives|June 4, 2010
The antipsychotic potential of muscarinic allosteric modulationThomas M Bridges, Evan P LeBois, Corey R Hopkins, et al.
Chemical Science|August 30, 2024
The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by <i>ent</i>-verticilideMadelaine P Thorpe, Abigail N Smith, Daniel J Blackwell, et al.
ACS Medicinal Chemistry Letters|May 19, 2022
Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1Swagat Sharma, Qi Peng, Anish K Vadukoot, et al.
Bioorganic & Medicinal Chemistry Letters|October 28, 2011
Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulatorThomas Utley, Dustin Haddenham, James M Salovich, et al.
Chemical Reviews|February 17, 2016
Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsCraig W Lindsley, Kyle A Emmitte, Corey R Hopkins, et al.
Chemmedchem|May 13, 2022
Further Exploration of the Benzimidazole Scaffold as TRPC5 Inhibitors: Identification of 1-Alkyl-2-(pyrrolidin-1-yl)-1H-benzo[d]imidazoles as Potent and Selective InhibitorsSwagat Sharma, Juan L Pablo, Kirsten T Tolentino, et al.
Journal of Medicinal Chemistry|July 17, 2012
Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitorYiu-Yin Cheung, Haibo Yu, Kaiping Xu, et al.
ACS Combinatorial Science|February 23, 2011
Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu₄Yiu-Yin Cheung, Rocio Zamorano, Anna L Blobaum, et al.
Bioorganic & Medicinal Chemistry Letters|July 31, 2009
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)Richard Williams, Kari A Johnson, Patrick R Gentry, et al.
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