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Journal of Medicinal Chemistry|January 30, 2007
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xLMilan Bruncko, Thorsten K Oost, Barbara A Belli, et al.Chemical Biology & Drug Design|July 17, 2007
Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategiesJeffrey R Huth, Chang Park, Andrew M Petros, et al.Journal of Medicinal Chemistry|April 4, 2017
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain InhibitorsLe Wang, John K Pratt, Todd Soltwedel, et al.Science Translational Medicine|March 20, 2015
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapyJoel D Leverson, Darren C Phillips, Michael J Mitten, et al.Nature|May 20, 2005
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursTilman Oltersdorf, Steven W Elmore, Alexander R Shoemaker, et al.ACS Medicinal Chemistry Letters|October 16, 2020
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL InhibitorLe Wang, George A Doherty, Andrew S Judd, et al.Nature Medicine|January 8, 2013
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing plateletsAndrew J Souers, Joel D Leverson, Erwin R Boghaert, et al.Pageof 9