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Methods in Molecular Biology (Clifton, N.J.)|September 19, 2017
Fed-Batch CHO Cell Culture for Lab-Scale Antibody ProductionYuzhou Fan, Daniel Ley, Mikael Rørdam Andersen
Journal of Biotechnology|August 30, 2019
BCAT1 and BCAT2 disruption in CHO cells has cell line-dependent effectsSara Pereira, Daniel Ley, Mikkel Schubert, et al.
Biotechnology and Bioengineering|May 22, 2015
Multi-omic profiling -of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein productionDaniel Ley, Ali Kazemi Seresht, Mikael Engmark, et al.
Scientific Reports|January 17, 2017
Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretionThomas Beuchert Kallehauge, Shangzhong Li, Lasse Ebdrup Pedersen, et al.
Metabolic Engineering|September 19, 2019
Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretionDaniel Ley, Sara Pereira, Lasse Ebdrup Pedersen, et al.
Nature Communications|January 4, 2020
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretionJahir M Gutierrez, Amir Feizi, Shangzhong Li, et al.
Nature Communications|April 22, 2020
Multiplex secretome engineering enhances recombinant protein production and purityStefan Kol, Daniel Ley, Tune Wulff, et al.
Nature Metabolism|January 14, 2025
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cellsHooman Hefzi, Iván Martínez-Monge, Igor Marin de Mas, et al.
Biorxiv : the Preprint Server for Biology|August 30, 2024
Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cellsHooman Hefzi, Iván Martínez-Monge, Igor Marin de Mas, et al.
Cell Systems|November 25, 2016
A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell MetabolismHooman Hefzi, Kok Siong Ang, Michael Hanscho, et al.
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