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Science Signaling|May 20, 2025
Loss-of-function Gαs rare disease variants exert mutation-specific effects on GPCR signalingTheo Redfern-Nichols, Shannon L O'Brien, Xianglin Huang, et al.Journal of Medicinal Chemistry|July 24, 2024
Design, Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Microscopy of Wild-Type ReceptorsAntonios Drakopoulos, Zsombor Koszegi, Kerstin Seier, et al.Molecular Cell|November 17, 2020
Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRsEva Marie Pfeil, Julian Brands, Nicole Merten, et al.Frontiers in Endocrinology|August 22, 2022
Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5 homo- and hetero-dimer formationDonatella Treppiedi, Giusy Marra, Genesio Di Muro, et al.Journal of Molecular Biology|July 5, 2021
Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?Caitlin Walker, Yingjie Wang, Cristina Olivieri, et al.Human Gene Therapy|June 24, 2004
Low-density lipoprotein (LDL) receptor/transferrin fusion protein: in vivo production and functional evaluation as a potential therapeutic tool for lowering plasma LDL cholesterolGiorgia Razzini, Flavia Parise, Davide Calebiro, et al.Neuroendocrinology|October 2, 2019
Cytoskeleton Protein Filamin A Is Required for Efficient Somatostatin Receptor Type 2 Internalization and Recycling through Rab5 and Rab4 Sorting Endosomes in Tumor Somatotroph CellsDonatella Treppiedi, Federica Mangili, Elena Giardino, et al.The Journal of Clinical Endocrinology and Metabolism|July 6, 2019
Somatic PRKACA Mutations: Association With Transition From Pituitary-Dependent to Adrenal-Dependent Cushing SyndromeGuido Di Dalmazi, Henri J L M Timmers, Giorgio Arnaldi, et al.Science Advances|February 20, 2021
PKA Cα subunit mutation triggers caspase-dependent RIIβ subunit degradation via Ser114 phosphorylationIsabel Weigand, Cristina L Ronchi, Jens T Vanselow, et al.Science Advances|September 7, 2019
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificityCaitlin Walker, Yingjie Wang, Cristina Olivieri, et al.Pageof 10