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Bioorganic & Medicinal Chemistry Letters|May 25, 2010
Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disordersTammy Ladduwahetty, Myra Gilligan, Alexander Humphries, et al.Journal of Medicinal Chemistry|November 13, 2004
An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing propertiesMark S Chambers, John R Atack, Robert W Carling, et al.Bioorganic & Medicinal Chemistry Letters|July 5, 2005
4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomniaL Rebecca Fish, Myra T Gilligan, Alexander C Humphries, et al.Bioorganic & Medicinal Chemistry Letters|November 24, 2005
Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunctionPhilip Jones, John R Atack, Matthew P Braun, et al.Journal of Medicinal Chemistry|September 16, 2005
A new pyridazine series of GABAA alpha5 ligandsMonique B van Niel, Kevin Wilson, Charles H Adkins, et al.Bioorganic & Medicinal Chemistry Letters|November 5, 2015
Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognitionJohn M Ellard, Andrew Madin, Oliver Philps, et al.Journal of Medicinal Chemistry|March 19, 2004
3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1Robert W Carling, Kevin W Moore, Leslie J Street, et al.Journal of Medicinal Chemistry|January 11, 2002
4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonistsStephen R Fletcher, Frank Burkamp, Peter Blurton, et al.Journal of Medicinal Chemistry|April 16, 2004
Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancersFrancine Sternfeld, Robert W Carling, Richard A Jelley, et al.Bioorganic & Medicinal Chemistry Letters|August 7, 2012
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathwayIan Bruce, Mohammed Akhlaq, Graham C Bloomfield, et al.Pageof 3