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Nature Microbiology|May 31, 2022
CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosisShuqi Li, Nicholas C Poulton, Jesseon S Chang, et al.
European Journal of Medicinal Chemistry|April 17, 2026
Structure-Activity relationship and optimization of drug-like properties of antituberculosis 3-(4,4-dimethyl-1,4-azasilinane)methylpyrazole MmpL3 inhibitorsLutete Peguy Khonde, Nashied Peton, Keabetswe Masike, et al.
Cell Host & Microbe|March 11, 2008
Selective killing of nonreplicating mycobacteriaRuslana Bryk, Benjamin Gold, Aditya Venugopal, et al.
Plos Pathogens|March 4, 2014
Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infectionAlexandre Gouzy, Gérald Larrouy-Maumus, Daria Bottai, et al.
Nature|June 21, 2019
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classesEachan O Johnson, Emily LaVerriere, Emma Office, et al.
Journal of Medicinal Chemistry|January 17, 2025
Metabolically Stable Adenylation Inhibitors of Biotin Protein Ligase as Antibacterial AgentsQiang Liu, Curtis A Engelhart, Joshua B Wallach, et al.
ACS Infectious Diseases|January 18, 2019
Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin SynthaseMatthew R Bockman, Curtis A Engelhart, Julia D Cramer, et al.
Biorxiv : the Preprint Server for Biology|October 3, 2025
Structure-Guided Development of a Potent BioA Inhibitor Validates Biotin Synthesis Inhibition as a Therapeutic Strategy for TuberculosisQiang Liu, Joshua B Wallach, Yahani P Jayasinghe, et al.
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