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Acta Crystallographica. Section F, Structural Biology Communications|March 6, 2020
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitorDouglas J Marcotte, Kerri A Spilker, Dingyi Wen, et al.
Chemmedchem|March 14, 2024
Discovery of Potent Isoindolinone Inhibitors that Target an Active Conformation of PARP1 Using DNA-Encoded LibrariesKelly A McCarthy, Douglas J Marcotte, Sangram Parelkar, et al.
BMC Structural Biology|June 2, 2016
Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligandDouglas J Marcotte, YuTing Liu, Kevin Little, et al.
Cellular and Molecular Neurobiology|May 20, 2020
Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) IsoformsChanna Bao, Bekim Bajrami, Douglas J Marcotte, et al.
ACS Medicinal Chemistry Letters|April 16, 2020
Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) InhibitorsZhili Xin, Martin K Himmelbauer, J Howard Jones, et al.
Protein Science : a Publication of the Protein Society|December 28, 2017
Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine-based inhibitor co-crystal structureDouglas J Marcotte, Jean-Christophe Hus, Charles C Banos, et al.
Journal of Medicinal Chemistry|November 12, 2019
Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 InhibitorsMartin K Himmelbauer, Zhili Xin, J Howard Jones, et al.
Protein Science : a Publication of the Protein Society|January 7, 2010
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinasesDouglas J Marcotte, Yu-Ting Liu, Robert M Arduini, et al.
Bioorganic & Medicinal Chemistry Letters|May 22, 2012
Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitorsJean-Yves Le Brazidec, Angela Pasis, Betty Tam, et al.
Journal of Medicinal Chemistry|October 15, 2021
Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In VivoJ Howard Jones, Zhili Xin, Martin Himmelbauer, et al.
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