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Bioorganic & Medicinal Chemistry Letters|June 3, 2023
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitorsNeil P Grimster, Lakshmaiah Gingipalli, Amber Balazs, et al.Bioorganic & Medicinal Chemistry Letters|July 28, 2020
Optimization of a series of potent, selective and orally bioavailable SYK inhibitorsNeil P Grimster, Lakshmaiah Gingipalli, Bernard Barlaam, et al.Communications Biology|May 13, 2024
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTACThomas G Hayhow, Beth Williamson, Mandy Lawson, et al.Journal of Medicinal Chemistry|February 6, 2020
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12CJason G Kettle, Sharan K Bagal, Sue Bickerton, et al.Journal of Medicinal Chemistry|April 26, 2022
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12CJason G Kettle, Sharan K Bagal, Sue Bickerton, et al.Journal of Medicinal Chemistry|July 3, 2023
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS PenetrationJason G Kettle, Sharan K Bagal, Derek Barratt, et al.Journal of Medicinal Chemistry|September 3, 2025
Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human KinomeAvipsa Ghosh, Afshan Ahmed, Konstantina Amoiradaki, et al.Journal of Medicinal Chemistry|February 10, 2025
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 InhibitorJason D Shields, David Baker, Amber Y S Balazs, et al.Pageof 3