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Journal of Medicinal Chemistry
|
March 2, 2018
Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization
Maarten L J Doornbos, Xuesong Wang, Sophie C Vermond, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 26, 2009
Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor
Gary Tresadern, Jose María Cid, Gregor J Macdonald, et al.
The Journal of Biological Chemistry
|
May 10, 2023
Selective inhibitors of the PSEN1-gamma-secretase complex
Lutgarde Serneels, Rajeshwar Narlawar, Laura Perez-Benito, et al.
Living Journal of Computational Molecular Science
|
November 16, 2022
Best practices for constructing, preparing, and evaluating protein-ligand binding affinity benchmarks [Article v0.1]
David F Hahn, Christopher I Bayly, Hannah E Bruce Macdonald, et al.
Heliyon
|
January 2, 2023
Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer
Tsehai A J Grell, Mark Mason, Aaron A Thompson, et al.
The Journal of Biological Chemistry
|
April 15, 2018
Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors
Marcel J C Bijvelds, Gary Tresadern, Ann Hellemans, et al.
ACS Omega
|
June 20, 2017
Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches
Frederik J R Rombouts, Richard Alexander, Erna Cleiren, et al.
ACS Medicinal Chemistry Letters
|
January 21, 2022
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo
Aldo Peschiulli, Daniel Oehlrich, Michiel Van Gool, et al.
Journal of Medicinal Chemistry
|
October 27, 2020
[1,2,4]Triazolo[1,5-<i>a</i>]pyrimidine Phosphodiesterase 2A Inhibitors: Structure and Free-Energy Perturbation-Guided Exploration
Gary Tresadern, Ingrid Velter, Andrés A Trabanco, et al.
Journal of Medicinal Chemistry
|
June 2, 2012
Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators
Francois Bischoff, Didier Berthelot, Michel De Cleyn, et al.
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Search research articles
Search
Showing results (71-80 of 99) with videos related to
Sort By:
Page
of 10
Journal of Medicinal Chemistry
|
March 2, 2018
Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization
Maarten L J Doornbos, Xuesong Wang, Sophie C Vermond, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 26, 2009
Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor
Gary Tresadern, Jose María Cid, Gregor J Macdonald, et al.
The Journal of Biological Chemistry
|
May 10, 2023
Selective inhibitors of the PSEN1-gamma-secretase complex
Lutgarde Serneels, Rajeshwar Narlawar, Laura Perez-Benito, et al.
Living Journal of Computational Molecular Science
|
November 16, 2022
Best practices for constructing, preparing, and evaluating protein-ligand binding affinity benchmarks [Article v0.1]
David F Hahn, Christopher I Bayly, Hannah E Bruce Macdonald, et al.
Heliyon
|
January 2, 2023
Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer
Tsehai A J Grell, Mark Mason, Aaron A Thompson, et al.
The Journal of Biological Chemistry
|
April 15, 2018
Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors
Marcel J C Bijvelds, Gary Tresadern, Ann Hellemans, et al.
ACS Omega
|
June 20, 2017
Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches
Frederik J R Rombouts, Richard Alexander, Erna Cleiren, et al.
ACS Medicinal Chemistry Letters
|
January 21, 2022
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo
Aldo Peschiulli, Daniel Oehlrich, Michiel Van Gool, et al.
Journal of Medicinal Chemistry
|
October 27, 2020
[1,2,4]Triazolo[1,5-<i>a</i>]pyrimidine Phosphodiesterase 2A Inhibitors: Structure and Free-Energy Perturbation-Guided Exploration
Gary Tresadern, Ingrid Velter, Andrés A Trabanco, et al.
Journal of Medicinal Chemistry
|
June 2, 2012
Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators
Francois Bischoff, Didier Berthelot, Michel De Cleyn, et al.
Page
of 10