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The Journal of Pharmacology and Experimental Therapeutics|May 23, 2018
Linaclotide Attenuates Visceral Organ Crosstalk: Role of Guanylate Cyclase-C Activation in Reversing Bladder-Colon Cross-SensitizationEhsan N Mohammadi, Casey O Ligon, Ada Silos-Santiago, et al.
Investigative Ophthalmology & Visual Science|March 22, 2016
The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse EyesPei Ge, Iris D Navarro, Marco M Kessler, et al.
Physiological Reports|June 9, 2017
Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestineMd Kaimul Ahsan, Boris Tchernychev, Marco M Kessler, et al.
International Journal of Oncology|March 10, 2006
Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458Gerhard Hannig, Douglas D Lazarus, Sylvie G Bernier, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|April 28, 2006
A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivoAndrew C Cooper, Russell M Karp, Edward J Clark, et al.
Bioorganic & Medicinal Chemistry Letters|March 23, 2010
Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonistsGhotas Evindar, Sylvie G Bernier, Elisabeth Doyle, et al.
The Journal of Pharmacology and Experimental Therapeutics|October 24, 2012
Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipationRobert W Busby, Marco M Kessler, Wilmin P Bartolini, et al.
Bioorganic & Medicinal Chemistry Letters|December 17, 2008
Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonistsGhotas Evindar, Sylvie G Bernier, Malcolm J Kavarana, et al.
JCI Insight|October 6, 2017
Guanylate cyclase 2C agonism corrects CFTR mutantsKavisha Arora, Yunjie Huang, Kyushik Mun, et al.
The Journal of Pharmacology and Experimental Therapeutics|July 29, 2015
MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP EffluxBoris Tchernychev, Pei Ge, Marco M Kessler, et al.
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