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Journal of Medicinal Chemistry
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July 10, 2015
Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)
Gregory S Basarab, Peter Doig, Vincent Galullo, et al.
ACS Medicinal Chemistry Letters
|
August 20, 2015
Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens
David C McKinney, Gregory S Basarab, Alexis I Cocozaki, et al.
Antimicrobial Agents and Chemotherapy
|
August 28, 2024
Dose-fractionation studies of a <i>Plasmodium</i> phosphatidylinositol 4-kinase inhibitor in a humanized mouse model of malaria
Liezl Gibhard, Mathew Njoroge, Mwila Mulubwa, et al.
Journal of Medicinal Chemistry
|
June 12, 2018
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria
Nishanth Kandepedu, Diego Gonzàlez Cabrera, Srinivas Eedubilli, et al.
The Journal of Biological Chemistry
|
July 8, 2015
Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914
Gunther Kern, Tiffany Palmer, David E Ehmann, et al.
Macromolecular Bioscience
|
March 31, 2023
A Water-Soluble Polymer-Lumefantrine Conjugate for the Intravenous Treatment of Severe Malaria
William M R Matshe, Lesego L Tshweu, Sindisiwe Mvango, et al.
Antimicrobial Agents and Chemotherapy
|
November 12, 2014
In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria
Michael D Huband, Patricia A Bradford, Linda G Otterson, et al.
ACS Medicinal Chemistry Letters
|
January 14, 2026
A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action
Mokhitli Morake, Dale Taylor, Dina Coertzen, et al.
Journal of Medicinal Chemistry
|
September 27, 2018
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains
Claire Le Manach, Tanya Paquet, Kathryn Wicht, et al.
Journal of Medicinal Chemistry
|
May 2, 2022
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity
Preshendren Govender, Rudolf Müller, Kawaljit Singh, et al.
Page
of 5
Search research articles
Search
Showing results (21-30 of 43) with videos related to
Sort By:
Page
of 5
Journal of Medicinal Chemistry
|
July 10, 2015
Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)
Gregory S Basarab, Peter Doig, Vincent Galullo, et al.
ACS Medicinal Chemistry Letters
|
August 20, 2015
Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens
David C McKinney, Gregory S Basarab, Alexis I Cocozaki, et al.
Antimicrobial Agents and Chemotherapy
|
August 28, 2024
Dose-fractionation studies of a <i>Plasmodium</i> phosphatidylinositol 4-kinase inhibitor in a humanized mouse model of malaria
Liezl Gibhard, Mathew Njoroge, Mwila Mulubwa, et al.
Journal of Medicinal Chemistry
|
June 12, 2018
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria
Nishanth Kandepedu, Diego Gonzàlez Cabrera, Srinivas Eedubilli, et al.
The Journal of Biological Chemistry
|
July 8, 2015
Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914
Gunther Kern, Tiffany Palmer, David E Ehmann, et al.
Macromolecular Bioscience
|
March 31, 2023
A Water-Soluble Polymer-Lumefantrine Conjugate for the Intravenous Treatment of Severe Malaria
William M R Matshe, Lesego L Tshweu, Sindisiwe Mvango, et al.
Antimicrobial Agents and Chemotherapy
|
November 12, 2014
In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria
Michael D Huband, Patricia A Bradford, Linda G Otterson, et al.
ACS Medicinal Chemistry Letters
|
January 14, 2026
A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action
Mokhitli Morake, Dale Taylor, Dina Coertzen, et al.
Journal of Medicinal Chemistry
|
September 27, 2018
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains
Claire Le Manach, Tanya Paquet, Kathryn Wicht, et al.
Journal of Medicinal Chemistry
|
May 2, 2022
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity
Preshendren Govender, Rudolf Müller, Kawaljit Singh, et al.
Page
of 5