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Bioorganic & Medicinal Chemistry Letters|March 6, 2019
Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimizationKosuke Anan, Moriyasu Masui, Aya Tazawa, et al.
Bioorganic & Medicinal Chemistry Letters|May 29, 2018
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screeningHiroyuki Tobinaga, Takayuki Kameyama, Miho Oohara, et al.
Bioorganic & Medicinal Chemistry Letters|February 4, 2021
Dioxotriazine derivatives as a new class of P2X3 receptor antagonists: Identification of a lead and initial SAR studiesHiroyuki Kai, Tohru Horiguchi, Takayuki Kameyama, et al.
Bioorganic & Medicinal Chemistry Letters|May 29, 2007
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: orally bioavailable compoundsHiroyuki Kai, Yasuhide Morioka, Minoru Tomida, et al.
Bioorganic & Medicinal Chemistry Letters|May 25, 2007
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: discovery of CB2 receptor selective compoundsHiroyuki Kai, Yasuhide Morioka, Takami Murashi, et al.
Bioorganic & Medicinal Chemistry Letters|September 29, 2021
Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonistsHiroyuki Kai, Tohru Horiguchi, Takayuki Kameyma, et al.
Bioorganic & Medicinal Chemistry Letters|February 8, 2019
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compoundsHiroyuki Tobinaga, Takayuki Kameyama, Kentarou Asahi, et al.
Bioorganic & Medicinal Chemistry Letters|November 2, 2020
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivativesHiroyuki Tobinaga, Takayuki Kameyama, Kentarou Asahi, et al.
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