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Bioorganic & Medicinal Chemistry Letters|March 7, 2001
Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferaseC J Dinsmore, J M Bergman, D D Wei, et al.Journal of Medicinal Chemistry|November 14, 1997
Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 positionT J Tucker, W C Lumma, S D Lewis, et al.Bioorganic & Medicinal Chemistry Letters|January 5, 1999
C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorptionR C Isaacs, K J Cutrona, C L Newton, et al.Bioorganic & Medicinal Chemistry Letters|January 1, 1999
L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitorP E Sanderson, K J Cutrona, B D Dorsey, et al.Journal of Medicinal Chemistry|November 26, 1997
Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 positionD M Feng, S J Gardell, S D Lewis, et al.Journal of Medicinal Chemistry|February 17, 1998
Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid supportS F Brady, K J Stauffer, W C Lumma, et al.Journal of Medicinal Chemistry|September 9, 2000
Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitorsB D Dorsey, C McDonough, S L McDaniel, et al.Journal of Medicinal Chemistry|August 14, 1998
Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 positionT J Tucker, S F Brady, W C Lumma, et al.Bioorganic & Medicinal Chemistry Letters|July 19, 2001
Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferaseD C Beshore, I M Bell, C J Dinsmore, et al.Journal of Medicinal Chemistry|November 7, 1998
Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templatesP E Sanderson, T A Lyle, K J Cutrona, et al.Pageof 10