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Endocrine-Related Cancer|November 28, 2017
Structure and function of RET in multiple endocrine neoplasia type 2Iván Plaza-MenachoJournal of Advanced Research|May 20, 2022
Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggabilityMoustafa A Shehata, Julia Contreras, Ana Martín-Hurtado, et al.Molecular Cell|February 25, 2014
Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in transIván Plaza-Menacho, Karin Barnouin, Kerry Goodman, et al.Proceedings of the National Academy of Sciences of the United States of America|December 29, 2019
Hybrid histidine kinase activation by cyclic di-GMP-mediated domain liberationBadri N Dubey, Elia Agustoni, Raphael Böhm, et al.Cell Reports|December 24, 2016
RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane ElementsIván Plaza-Menacho, Karin Barnouin, Rachael Barry, et al.The Journal of Biological Chemistry|August 1, 2007
Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targetingIván Plaza-Menacho, Luca Mologni, Elisa Sala, et al.The Journal of Biological Chemistry|April 2, 2011
Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanismIván Plaza-Menacho, Andrea Morandi, Luca Mologni, et al.Nature Communications|March 6, 2026
The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinaseAna Martín-Hurtado, Julia Contreras, Jana Sánchez-Wandelmer, et al.Nature Communications|October 17, 2023
An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src functionHipólito Nicolás Cuesta-Hernández, Julia Contreras, Pablo Soriano-Maldonado, et al.Pageof 2