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Journal of Medicinal Chemistry|March 2, 2026
Optimization of Covalent Warhead Trajectory for KRASG12C Active-State InhibitionMatthew L Condakes, Rita L Civiello, Sirish Kaushik Lakkaraju, et al.ACS Medicinal Chemistry Letters|March 21, 2019
Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's DiseaseJoseph D Panarese, Darren W Engers, Yong-Jin Wu, et al.Bioorganic & Medicinal Chemistry Letters|July 4, 2007
N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitorsMichael F Parker, Donna M Barten, Carl P Bergstrom, et al.ACS Medicinal Chemistry Letters|March 18, 2016
Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5Fukang Yang, Lawrence B Snyder, Anand Balakrishnan, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase InhibitorKevin W Gillman, John E Starrett, Michael F Parker, et al.Bioorganic & Medicinal Chemistry Letters|November 17, 2010
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1Lawrence R Marcin, Mendi A Higgins, F Christopher Zusi, et al.Bioorganic & Medicinal Chemistry Letters|December 4, 2018
The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidateJoseph D Panarese, Darren W Engers, Yong-Jin Wu, et al.Journal of Medicinal Chemistry|July 16, 2021
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic PainRichard A Hartz, Vijay T Ahuja, Susheel J Nara, et al.ACS Chemical Neuroscience|October 18, 2016
Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of DepressionAndrew P Degnan, George O Tora, Hong Huang, et al.Bioorganic & Medicinal Chemistry Letters|May 5, 2005
Biaryl isoxazolinone antibacterial agentsClaude A Quesnelle, Patrice Gill, Stephan Roy, et al.Pageof 12