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Cardiovascular Therapeutics|July 17, 2009
Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonistSteen Husted, J J J van GiezenSeminars in Thrombosis and Hemostasis|April 27, 2005
Preclinical and clinical studies with selective reversible direct P2Y12 antagonistsJ J J van Giezen, Robert G HumphriesThrombosis Research|August 21, 2009
Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasisJ J J van Giezen, Pia Berntsson, Helen Zachrisson, et al.Platelets|November 26, 2005
Evaluation of platelet function, a method comparisonS Nylander, K Johansson, J J J Van Giezen, et al.Thrombosis Research|August 23, 2012
Evaluation of ticagrelor pharmacodynamic interactions with reversibly binding or non-reversibly binding P2Y(12) antagonists in an ex-vivo canine modelAnna Ravnefjord, Jessika Weilitz, Britt-Marie Emanuelsson, et al.Journal of Cardiovascular Pharmacology and Therapeutics|June 24, 2011
Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hyperemia responses in a canine modelJ J J van Giezen, James Sidaway, Philip Glaves, et al.Journal of Cardiovascular Pharmacology and Therapeutics|January 14, 2014
Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1Duncan Armstrong, Claire Summers, Lorna Ewart, et al.Thrombosis and Haemostasis|August 10, 2010
Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis modelKai Wang, Xiaorong Zhou, Yanming Huang, et al.Journal of the American College of Cardiology|January 15, 2013
Ticagrelor enhances adenosine-induced coronary vasodilatory responses in humansAnn Wittfeldt, Håkan Emanuelsson, Gunnar Brandrup-Wognsen, et al.Journal of Thrombosis and Haemostasis : JTH|June 26, 2009
Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregationJ J J VAN Giezen, L Nilsson, P Berntsson, et al.Pageof 2