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Scientific Reports|June 4, 2016
Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to ManAnthony L Gotter, Mark S Forman, Charles M Harrell, et al.
Bioorganic & Medicinal Chemistry Letters|November 26, 2015
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophreniaIzzat T Raheem, John D Schreier, Joy Fuerst, et al.
Bioorganic & Medicinal Chemistry Letters|January 12, 2015
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexantIzzat T Raheem, Michael J Breslin, Joseph Bruno, et al.
Bioorganic & Medicinal Chemistry Letters|August 3, 2010
Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonistsKelly-Ann S Schlegel, Zhi-Qiang Yang, Thomas S Reger, et al.
Bioorganic & Medicinal Chemistry Letters|February 15, 2011
Pyridyl amides as potent inhibitors of T-type calcium channelsThomas S Reger, Zhi-Qiang Yang, Kelly-Ann S Schlegel, et al.
Science Translational Medicine|April 5, 2013
Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognitionJason M Uslaner, Spencer J Tye, Donnie M Eddins, et al.
Chemmedchem|May 7, 2009
Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in ratsDavid B Whitman, Christopher D Cox, Michael J Breslin, et al.
Bioorganic & Medicinal Chemistry Letters|February 21, 2017
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonistsJason W Skudlarek, Christina N DiMarco, Kerim Babaoglu, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel AntagonistsJames C Barrow, Kenneth E Rittle, Thomas S Reger, et al.
Chemmedchem|December 31, 2013
Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaAnthony J Roecker, Swati P Mercer, John D Schreier, et al.
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